3. Cersei Lannister (Game of Thrones)
Lena Headey plays Cersei Lannister on HBO’s Game of Thrones.
Credit: Helen SloanLena Headey plays Cersei Lannister on HBO’s Game of Thrones.
Now that her tantrum-happy son Joffrey is dead (spoiler alert), Cersei (Lena Headey) has taken her rightful place as Game of Thrones’ public enemy no. 1. Arguably, the Queen Regent has always been the HBO series’ biggest villain, but in season 4, she kicked things up a notch. Blindsided by the death of her son, Cersei adamantly condemned her brother Tyrion for Joffrey’s murder, sentencing him to death. Plus, there’s that whole having-sex-with-her-brother-next-to-their-dead-son’s-corpse thing.